The crusade of medical marijuana has been a long, strange trip. These days, using marijuana for depression is becoming more common; let’s see why. 

Nations all across the globe have been smoking the ‘erb for at least 4000 years. Doctors in the US prescribed it often until the 1930s. Marketers even used to advertise it to moms for teething problems in babies. 

Depression affects millions of people daily. This complex disorder affects your mood, emotions, and physical health. The medicinal use of weed strains for depression is equally complex, and researchers are still studying the relationship between these two. Read on as we explore recent developments in marijuana strains for depression and take a look at the top-rated buds for alleviating it.


5 Best strains for depression


Can I really use marijuana for depression?

According to the World Health Organization (WHO), depression is one of the top causes of disability worldwide. It affects over 260 million people from all demographics. No wonder people are looking for the best cannabis strains for depression.

Unshakable sadness and a lack of interest in activities you once enjoyed are tell-tale signs of depression. 

This disease is crippling, and as such, the markets are packed with various pharmaceutical treatments. Researchers are now looking into the medicinal use of marijuana as a natural treatment option. Here are some of the reported benefits of using marijuana for depression:

  • It can relieve symptoms of anxiety and depression. 
  • You can use it to manage pain. 
  • It offers immediate relief. 
  • Avoid side effects associated with the use of conventional pharmaceuticals, like anxiety, agitation, and lethargy. 

THC and CBD both play a big role in relieving symptomsbut flavonoids, terpenes, and minor cannabinoids also bring medicinal properties to the table. 

A study published by the University of New Mexico found that about three in five people reported positive side effects, such as happiness, peacefulness, and relaxation when using marijuana for depression

Let’s take a look at some of the best marijuana strains for depression. 



Harlequin is the embodiment of a relaxed high. Its high CBD (7%) content makes it the perfect medical marijuana strain for depression, as it counters the anxiety that THC may induce. 

Well known for its medicinal properties, this variety typically boasts a THC to CBD ratio of 2:5. 

Alongside its mood-boosting properties, you can expect a clear head and none of the psychoactive properties of a THC-induced high. If you’re looking for the best sativa strain for depression, this is it. 

The primary terpenes are myrcene, pinene, and caryophyllene. The terpene profile adds to the pleasant, relaxing feeling without worsening your anxiety

Let’s not bench the THC, though. The low levels ease stress and fatigue while boosting mental clarity. The healthy balance of THC and CBD lets folks with depression function in ways they otherwise wouldn’t be able to. No wonder smokers choose CBD strains for depression


Granddaddy Purple

Granddaddy Purple is an all-around sensory experience—it’s a great toke and a sight to behold with its lush purple buds. Aromas of blueberry and grape take you on a positively overwhelming high.

This heavy hitter is one of the best strains for anxiety and depression as it forces you to relax and unwind

The relatively high THC content (around 20%) ensures a couch lock but leaves your mind sharp without any fogginess. This indica-dominant strain for depression is great for an evening puff after a particularly stressful day. The cerebral uplift has many people lighting it up to alleviate anxiety and depression. 

Granddaddy Purple is also great for users with a reduced appetite or insomnia. You’re pretty much guaranteed the munchies before eventually drifting into a solid slumber. 


5 Best strains for depression


Blackberry Kush

Blackberry Kush is another indica-dominant cannabis strain for depression

This cultivar is perfect for users whose worries keep them up at night. A hard-hitting total body high will leave you on the couch for hours in complete bliss. It’s not a social smoke, but it’ll replace any negative emotions with positive thoughts for a few much-needed hours of euphoria. 

Users love the easy cultivation process and the gorgeous dark purple tinted bud. 

This combination of blackberry and Afghani is a strong contender for one of the best weed strains for depression. She’s a staple in the treatment of many psychological disorders. When your mind wanders, and things start to feel heavy, this strain can quickly snap you out of it and have you focus on the positive. 


Jack Herer

Jack Herer has earned its spot as one of the most coveted medical marijuana strains for depression. You’ll only need a puff or two to feel the robust effects of this baby. 

This THC-dominant hybrid provides the ultimate balance between indica and sativa as she relaxes the body while lifting the mood. Aromas of pine and freshly cut wood can have you daydreaming of walks in the forest. 

She inspires creativity, and thanks to high levels of limonene, she’s one of the best marijuana strains for depression. It’s the perfect wake ‘n bake companion to deliver a dazzling rush on bad days. The bonus is that she’ll leave you focused for the day ahead

Jack Herer originally bred this strain for medicinal purposes. She’s reportedly excellent at treating the psychological symptoms of depression, anxiety, and PTSD. 

The fact that this auto can be grown by newbies is an added benefit.



Cannatonic is one of the most popular CBD strains for depression. You can expect a healthy CBD to THC ratio of 2:1 to act as your therapist. 

She boasts sharp citrusy and pine notes alongside a classic dank flavor profile. 

She’s one of the most successful medicinal strains ever bred, and her mood-boosting properties make it perfect for dealing with depression. The low THC content makes her the perfect fit for newbies or smokers with a low tolerance. 

Another benefit that cements her place among great strains of marijuana for depression is that she induces mental clarity. One of the biggest struggles of depression is the mental fogginess and lack of focus, making this cultivar the perfect fit. 

The odds of experiencing any adverse side effects are slim to none, making this possibly the best CBD strain for depression—all of the benefits and none of the paranoia or disorientation. 


5 Best strains for depression


Should I choose THC or CBD dominant strains for depression?

Choosing the best weed strains for depression is about a lot more than just the CBD and THC levels. You also have to understand the various terpenes and cannabinoids present. The best way to do this is by discussing it with a doctor. 

Your brain naturally produces endocannabinoids that affect your emotions, mood, and behavior. Depression occurs when your brain no longer produces enough of these chemicals. 

THC and CBD and the hundreds of other cannabinoids resemble the chemicals produced by your brain. Researchers opine that using marijuana for depression helps by restoring endocannabinoids in patients. 

The disease is different for all people. Similarly, the effects that THC and CBD have on people vary. 

High-THC buds are usually the preferred marijuana for depression. It stimulates the release of serotonin and dopamine, temporarily alleviating the symptoms. High concentrations of THC could cause panic attacks, anxiety, and psychosis. 

Long-term abuse of tetrahydrocannabinol (THC) could blunt your dopamine system, which leads to a permanent decline in the production of this crucial chemical.  

Cannabidiol (CBD), on the other hand, doesn’t offer its users a euphoric high. It’s believed to regulate the central nervous system, which treats various mental health disorders. This is why some folks prefer CBD strains for depression

Don’t dismiss the multiple terpenes that are found in marijuana. These chemicals are responsible for the delectable aromas that make many varieties popular. They also play a massive role in the effects you experience. 

The best cannabis strains for depression usually have high levels of certain terpenes contributing to their feel-good factors.  


Bye-bye depro vibes

Depression and how it reacts to treatment is a complex process that usually requires trial and error. Be patient while trying various strains, and remember to go low and slow while figuring it out. 

We’ve explored five variations of marijuana for depression, but there’s a vast world of medicinal marijuana to discover. Don’t let us stop you; go check out all the wonderful variety that Seed Supreme has to offer. 

Make sure to check in with your doctor to see if you qualify for a medical marijuana card. If it’s not legal in your state, chat to your doctor about alternative treatment options until it becomes an option. 

If it is legal, what are you waiting for? Grab one of the strains mentioned above, or even better, grow your own marijuana for depression.

Posted in: Medical CannabisNews